Kyle Manzardo was 3-for-4 with a homer and four RBIs Thursday for the Cleveland Guardians, who overcame a blown save by All-Star closer Emmanuel Clase to beat the host Kansas City Royals, 7-4, in 10 innings in an Opening Day clash.

Steven Kwan led off the 10th inning with the tie-breaking RBI double for the defending American League Central champion Guardians, who have won both their season openers under second-year manager Stephen Vogt.

Manzardo began the Guardians' comeback from a 3-0 deficit in the fourth, when he tripled and scored on a sacrifice fly by Jhonkensy Noel. Jose Ramirez lofted another sacrifice fly in the fifth before Manzardo greeted Angel Zerpa by hitting a two-run homer on the first pitch he saw in the sixth.

The 24-year-old, who made his first Opening Day roster this season, added insurance with a two-out, two-run double off Sam Long (0-1) in the 10th.

Paul Sewald earned the save with a perfect 10th.

Kwan had two hits.

Vinnie Pasquantino, who was questionable entering the game due to a right hamstring injury he suffered last Saturday, hit a three-run homer in the third before he began the Royals' comeback by lacing a leadoff double against Clase (1-0) in the ninth.

Salvador Perez followed with a single to send pinch-runner Freddy Fermin to third before Fermin trotted home on Michael Massey's sacrifice fly to the track in right.

Clase was 47-of-49 in regular season save opportunities last season, when he posted an 0.61 ERA and finished third in the American League Cy Young Award balloting, before he went 0-2 with a 9.00 ERA and two saves in three chances over seven playoff appearances.

Pasquantino was the only player with multiple hits for the Royals, who fell to 0-3 on Opening Day under manager Matt Quatraro.

Neither starter factored into the decision after five-inning outings.

The Guardians' Ben Lively, who was pressed into duty when Tanner Bibee was scratched due to food poisoning, gave up three runs on four hits and no walks while striking out three. The Royals' Cole Ragans allowed three runs on five hits and two walks while whiffing three.

The Kansas City Royals acquired outfielder/first baseman Mark Canha from the Milwaukee Brewers for a player to be named later or cash considerations, MLB.com reported.

Canha, 36, signed a minor league deal with the Brewers. He is just 2-for-23 with one homer, four strikeouts and four walks in Cactus League action.

Canha reportedly let the Brewers know he planned to exercise a clause in his contract that required the team to put him on the 40-man roster or allow him to become a free agent. As a result, the Brewers traded him to the Royals.

Per MLB.com, Canha could earn $1.4 million with performance bonuses in 2025 once he is elevated to the majors.

Canha batted .242 with seven homers and 42 RBIs in 125 games split between the Detroit Tigers and San Francisco Giants last season.

He is a .249 hitter with 120 homers, 459 RBIs and 514 runs in 1,049 career games for the Oakland A's (2015-21), New York Mets (2022-23), Brewers (2023), Tigers (2024) and Giants (2024).

Kansas City Royals

2024 record: 86-76 (2nd place, AL Central)

He gone: RHP Brady Singer.

New faces: RHP Carlos Estevez, INF Jonathan India, OF Joey Wiemer.

Biggest question entering Opening Day: Bobby Witt Jr. is going to be OK, right? X-rays came back negative after the Royals' shortstop was hit in the left forearm by a fastball during a March 12 spring training game. He suffered a contusion and will continue to be evaluated. Witt told reporters, "If it was October or April or March 27, I'd be good." Royals fans and brass hope his body was listening.

Top prospect: Kansas City chose 1B Jac Caglianone sixth overall in last season's draft after his solid college career at Florida. The slugger flexed his power during the spring but must increase his contact and limit his strikeouts -- note the lack of a "k" in his first name -- to keep developing.

Breakout player: OF Hunter Renfroe's first season in Kansas City wasn't what the club hoped for, as his power and overall production (15 HRs, 52 RBIs, .229 BA) last year dipped among injuries to his back, left toe and right hamstring. He came to spring training leaner and healthier and is determined to show he still wields a reliable and potent bat.

2025 outlook: The Royals transformed from a 106-loss squad in 2023 to an ALDS team one season later behind a solid pitching staff that compiled the No. 8 team ERA (3.76) in baseball. RHPs Seth Lugo and Michael Wacha and LHP Cole Ragans anchor a rotation built to get the ball to a bullpen that now flaunts Estevez, owner of 57 saves over the past two seasons. If new leadoff man India can help ignite an offense led by all-everything SS Witt Jr., runner-up in the AL MVP race to the Yankees' Aaron Judge last season, the Royals are primed to keep progressing in the playoffs. Witt finished with 32 HRs, 109 RBIs and a .332 BA in 2024.

Coming off his first All-Star campaign, Kansas City left-hander Cole Ragans agreed to a three-year extension with the Royals, the team announced Friday.

The Royals did not confirm financial terms, but multiple sources reported the deal is worth $13.25 million.

Ragans, 27, who will be a free agent following the 2028 season, will earn $1.25 million in 2025, $4.5 million in 2026 and $7.5 million in 2027, according to ESPN.

In his second season in Kansas City in 2024, Ragans emerged as the staff's ace and helped the club reach the postseason, posting an 11-9 record and a 3.14 ERA in 32 starts.

He led the American League with 10.8 strikeouts per nine innings, finishing with 223 whiffs along with 67 walks in 186 1/3 innings. In two postseason starts, he went 1-1 with a 0.90 ERA, allowing one run in 10 innings.

Ragans was a first-round pick (No. 30 overall) by the Texas Rangers in the 2016 draft, but endured two Tommy John surgeries and didn't reach the majors until 2022. After 26 appearances (nine starts) over two seasons with Texas, he was traded to the Royals in June 2023 in exchange for Aroldis Chapman and joined Kansas City's rotation.

In three seasons in the majors, Ragans is 18-17 with a 3.46 ERA in 70 games (53 starts) spanning 322 1/3 innings, with 363 strikeouts and 124 walks.

The Kansas City Royals have reached an agreement with free agent right-handed closer Carlos Estevez on a two-year contract, according to multiple media reports Wednesday evening.

Estevez, an All-Star in 2023 with the Los Angeles Angels, split last season between the Angels and the Philadelphia Phillies, who acquired him on July 27 ahead of the trade deadline last summer.

The contract is worth a reported $22 million, though the Royals are yet to confirm the deal.

Estevez, who turned 32 on Dec. 28, was a combined 4-5 with a 2.45 ERA, 26 saves, 12 walks and 50 strikeouts in 55 innings over 54 relief appearances last season.

He has a career 27-31 record with a 4.21 ERA, 82 saves, 161 walks and 440 strikeouts in 419 1/3 innings over 438 relief appearances for the Colorado Rockies (2016-17, 2019-22), Angels (2023-24) and Phillies (2024). He missed the 2018 season because of injuries.

Kansas City was 86-76 last season and made the playoffs for the first time since 2015, sweeping the Baltimore Orioles in the American League wild-card round 2-0 before falling to the New York Yankees in the ALDS 3-1.

Veteran right-hander Michael Lorenzen, who helped the Kansas City Royals earn a wild-card spot in the 2024 postseason, is re-signing with the club on a one-year contract, multiple media outlets reported Monday.

Per ESPN, Lorenzen agreed to a one-year, $7 million deal with a mutual $12 million option for 2026. MLB.com reported that the mutual option includes a $1.5 million buyout.

Acquired from the Texas Rangers in a trade deadline deal, the 33-year-old Lorenzen went 2-0 with a 1.57 ERA in 28 2/3 innings over seven games (six starts) with Kansas City. Overall in 2024, he was 7-6 with a 3.31 ERA in 130 1/3 innings over 26 games (24 starts).

The 10-year veteran was a first-round pick by the Reds in 2013 and spent his first seven seasons with Cincinnati (2015-21). Lorenzen, a 2023 All-Star, has also played for the Los Angeles Angels (2022), Detroit Tigers (2023) and Philadelphia Phillies (2023).

In 368 career games (93 starts), the Anaheim, Calif., native is 47-44 with a 3.99 ERA over 854 1/3 innings. In the playoffs, Lorenzen has gone 0-1 with a 1.17 ERA in 7 2/3 innings over six relief outings.